2023
Molecular Pharmaceutics, 2023, 20(1):582-592
Treatment of Orthotopic U251 Human Glioblastoma Multiforme Tumors in NRG Mice by Convection-Enhanced Delivery of Gold Nanoparticles Labeled with the B-Particle-Emitting Radionuclide, 177Lu
Constantine J. Georgiou, Zhongli Cai, Noor Alsaden, Hyungjun Cho, Minou Behboudi, Mitchell A. Winnik, James T. Rutka, and Raymond M. Reilly
Abstract
Treatment of Orthotopic U251 Human Glioblastoma Multiforme Tumors in NRG Mice by Convection-Enhanced Delivery of Gold Nanoparticles Labeled with the B-Particle-Emitting Radionuclide, 177Lu
Constantine J. Georgiou, Zhongli Cai, Noor Alsaden, Hyungjun Cho, Minou Behboudi, Mitchell A. Winnik, James T. Rutka, and Raymond M. Reilly
Abstract
2022
Molecular Pharmaceutics, 2022, 19(11):4199-4211
90Y-Labeled Gold Nanoparticle Depot (NPD) Combined with Anti-PD-L1 Antibodies Strongly Inhibits the Growth of 4T1 Tumors in Immunocompetent Mice and Induces an Abscopal Effect on a Distant Non-Irradiated Tumor
Zhongli Cai, Rella Liu, Conrad Chan, Yijie Lu, Mitchell A. Winnik, David W. Cescon, and Raymond M. Reilly
Abstract
90Y-Labeled Gold Nanoparticle Depot (NPD) Combined with Anti-PD-L1 Antibodies Strongly Inhibits the Growth of 4T1 Tumors in Immunocompetent Mice and Induces an Abscopal Effect on a Distant Non-Irradiated Tumor
Zhongli Cai, Rella Liu, Conrad Chan, Yijie Lu, Mitchell A. Winnik, David W. Cescon, and Raymond M. Reilly
Abstract
2021
Sci Transl Med. 2021 Oct 13.
MR-guided focused ultrasound enhances delivery of trastuzumab to Her2-positive brain metastases
Abstract
MR-guided focused ultrasound enhances delivery of trastuzumab to Her2-positive brain metastases
Abstract
2019
Wiley, 2019
Medical Imaging for Health Professionals: Technologies and Clinical Applications
Editor: Raymond M. Reilly
Medical Imaging for Health Professionals: Technologies and Clinical Applications
Editor: Raymond M. Reilly
2018
Nucl Med Biol. 2018 Dec;67:43-51
Tumor uptake and tumor/blood ratios for [89Zr]Zr-DFO-trastuzumab-DM1 on microPET/CT images in NOD/SCID mice with human breast cancer xenografts are directly correlated with HER2 expression and response to trastuzumab-DM1
Noor Al-saden, Zhongli Cai and Raymond M. Reilly
Abstract
Tumor uptake and tumor/blood ratios for [89Zr]Zr-DFO-trastuzumab-DM1 on microPET/CT images in NOD/SCID mice with human breast cancer xenografts are directly correlated with HER2 expression and response to trastuzumab-DM1
Noor Al-saden, Zhongli Cai and Raymond M. Reilly
Abstract
Molecular Pharmaceutics, 2018, 15(8):3383-3393
Positron-Emission Tomography of HER2-Positive Breast Cancer Xenografts in Mice with 89Zr-Labeled Trastuzumab-DM1: A Comparison with 89Zr-Labeled Trastuzumab
Noor Al-saden, Karen Lam, Conrad Chan and Raymond M. Reilly
Abstract
Positron-Emission Tomography of HER2-Positive Breast Cancer Xenografts in Mice with 89Zr-Labeled Trastuzumab-DM1: A Comparison with 89Zr-Labeled Trastuzumab
Noor Al-saden, Karen Lam, Conrad Chan and Raymond M. Reilly
Abstract
Molecular Pharmaceutics, 2018, 15(3):1150-1159
Panitumumab Modified with Metal-Chelating Polymers (MCP) Complexed to 111In and 177Lu -- An EGFR-Targeted Theranostic for Pancreatic Cancer
Sadaf Aghevlian, Yijie Lu, Mitchell A. Winnik, David W. Hedley and Raymond M. Reilly
Abstract
Panitumumab Modified with Metal-Chelating Polymers (MCP) Complexed to 111In and 177Lu -- An EGFR-Targeted Theranostic for Pancreatic Cancer
Sadaf Aghevlian, Yijie Lu, Mitchell A. Winnik, David W. Hedley and Raymond M. Reilly
Abstract
2017
ACS Biomaterials Science & Engineering, 2017, in press
EGFR-Targeted Metal Chelating Polymers (MCPs) Harboring Multiple Pendant PEG2K Chains for MicroPET/CT Imaging of Patient-Derived Pancreatic Cancer Xenografts
Yijie Lu, Amanda J. Boyle, Ping-Jiang Cao, David Hedley, Raymond M. Reilly, and Mitchell A. Winnik
Abstract
EGFR-Targeted Metal Chelating Polymers (MCPs) Harboring Multiple Pendant PEG2K Chains for MicroPET/CT Imaging of Patient-Derived Pancreatic Cancer Xenografts
Yijie Lu, Amanda J. Boyle, Ping-Jiang Cao, David Hedley, Raymond M. Reilly, and Mitchell A. Winnik
Abstract
Molecular Pharmaceutics, 2017, in press
64Cu-Labeled Trastuzumab Fab-PEG24-EGF Radioimmunoconjugates Bispecific for HER2 and EGFR: Pharmacokinetics, Biodistribution, and Tumor Imaging by PET in Comparison to Monospecific Agents.
Luke Yongkyu Kwon, Deborah Scollard, Raymond M. Reilly
PubMed Abstract
64Cu-Labeled Trastuzumab Fab-PEG24-EGF Radioimmunoconjugates Bispecific for HER2 and EGFR: Pharmacokinetics, Biodistribution, and Tumor Imaging by PET in Comparison to Monospecific Agents.
Luke Yongkyu Kwon, Deborah Scollard, Raymond M. Reilly
PubMed Abstract
MAbs., 2017, (1):154-164
Development and preclinical studies of 64Cu-NOTA-pertuzumab F(ab')2 for imaging changes in tumor HER2 expression associated with response to trastuzumab by PET/CT.
Karen Lam, Conrad Chan, Raymond M. Reilly
PubMed Abstract
Development and preclinical studies of 64Cu-NOTA-pertuzumab F(ab')2 for imaging changes in tumor HER2 expression associated with response to trastuzumab by PET/CT.
Karen Lam, Conrad Chan, Raymond M. Reilly
PubMed Abstract
2016
Pharmaceutical Research, 2016, in press
Local Radiation Treatment of HER2-Positive Breast Cancer Using Trastuzumab-Modified Gold Nanoparticles Labeled with 177Lu
Zhongli Cai, Simmyung Yook, Yijie Lu, Dane Bergstrom, Mitchell A Winnik, Jean-Philippe Pignol, Raymond M. Reilly
PubMed Abstract
Local Radiation Treatment of HER2-Positive Breast Cancer Using Trastuzumab-Modified Gold Nanoparticles Labeled with 177Lu
Zhongli Cai, Simmyung Yook, Yijie Lu, Dane Bergstrom, Mitchell A Winnik, Jean-Philippe Pignol, Raymond M. Reilly
PubMed Abstract
International Journal of Pharmaceutics, 2016, 515(1-2):729-739.
Depot system for controlled release of gold nanoparticles with precise intratumoral placement by permanent brachytherapy seed implantation (PSI) techniques.
Priscilla Lai, Eli Lechtman, Shahram Mashouf, Jean-Philippe Pignol, Raymond M. Reilly
PubMed Abstract
Depot system for controlled release of gold nanoparticles with precise intratumoral placement by permanent brachytherapy seed implantation (PSI) techniques.
Priscilla Lai, Eli Lechtman, Shahram Mashouf, Jean-Philippe Pignol, Raymond M. Reilly
PubMed Abstract
Nuclear Medicine and Biology, 2016, 43(12):818-826
111In-labeled trastuzumab-modified gold nanoparticles are cytotoxic in vitro to HER2-positive breast cancer cells and arrest tumor growth in vivo in athymic mice after intratumoral injection
Zhongli Cai, Niladri Chattopadhyay, Kaiyu Yang, Yongkyu Luke Kwon, Simmyung Yook, Jean-Philippe Pignol, Raymond M. Reilly
PubMed Abstract
111In-labeled trastuzumab-modified gold nanoparticles are cytotoxic in vitro to HER2-positive breast cancer cells and arrest tumor growth in vivo in athymic mice after intratumoral injection
Zhongli Cai, Niladri Chattopadhyay, Kaiyu Yang, Yongkyu Luke Kwon, Simmyung Yook, Jean-Philippe Pignol, Raymond M. Reilly
PubMed Abstract
Journal of Nuclear Medicine, 2016, in press
Monte-Carlo N-Particle (MCNP) Modeling of the Cellular Dosimetry of 64Cu - Comparison with MIRDcell S-Values and Implications for Studies of its Cytotoxic Effects.
Zhongli Cai, Yongkyu Luke Kwon, Raymond M. Reilly
PubMed Abstract
Monte-Carlo N-Particle (MCNP) Modeling of the Cellular Dosimetry of 64Cu - Comparison with MIRDcell S-Values and Implications for Studies of its Cytotoxic Effects.
Zhongli Cai, Yongkyu Luke Kwon, Raymond M. Reilly
PubMed Abstract
Nuclear Medicine and Biology, 2016, 43(10):635-41
Paradoxical effects of Auger electron-emitting 111In-DTPA-NLS-CSL360 radioimmunoconjugates on hCD45(+) cells in the bone marrow and spleen of leukemia-engrafted NOD/SCID or NRG mice.
Dane Bergstrom, Jeffrey V. Leyton, Arman Zereshkian, Conrad Chan, Zhongli Cai, Raymond M. Reilly
PubMed Abstract
Paradoxical effects of Auger electron-emitting 111In-DTPA-NLS-CSL360 radioimmunoconjugates on hCD45(+) cells in the bone marrow and spleen of leukemia-engrafted NOD/SCID or NRG mice.
Dane Bergstrom, Jeffrey V. Leyton, Arman Zereshkian, Conrad Chan, Zhongli Cai, Raymond M. Reilly
PubMed Abstract
Journal of Nuclear Medicine, 2016, 57(3):444-52.
Dual-Receptor-Targeted Radioimmunotherapy of Human Breast Cancer Xenografts in Athymic Mice Coexpressing HER2 and EGFR Using 177Lu- or 111In-Labeled Bispecific Radioimmunoconjugates.
Eva J. Razumienko, Jason C. Chen, Zhongli Cai, Conrad Chan, and Raymond M. Reilly
PubMed abstract
Dual-Receptor-Targeted Radioimmunotherapy of Human Breast Cancer Xenografts in Athymic Mice Coexpressing HER2 and EGFR Using 177Lu- or 111In-Labeled Bispecific Radioimmunoconjugates.
Eva J. Razumienko, Jason C. Chen, Zhongli Cai, Conrad Chan, and Raymond M. Reilly
PubMed abstract
Journal of Nuclear Medicine, 2016, 57(6):936-42
Intratumorally Injected 177Lu-Labeled Gold Nanoparticles - Gold Nanoseed Brachytherapy with Application for Neo-Adjuvant Treatment of Locally Advanced Breast Cancer (LABC).
Simmyung Yook , Zhongli Cai , Yijie Lu , Mitchell A. Winnik , Jean-Philippe Pignol, Raymond M. Reilly
PubMed abstract
Intratumorally Injected 177Lu-Labeled Gold Nanoparticles - Gold Nanoseed Brachytherapy with Application for Neo-Adjuvant Treatment of Locally Advanced Breast Cancer (LABC).
Simmyung Yook , Zhongli Cai , Yijie Lu , Mitchell A. Winnik , Jean-Philippe Pignol, Raymond M. Reilly
PubMed abstract
2015
Applied Radiation and Isotopes, 2015, 110:1-7.
Auger electron-emitting 111In-DTPA-NLS-CSL360 radioimmunoconjugates are cytotoxic to human acute myeloid leukemia (AML) cells displaying the CD123+/CD131- phenotype of leukemia stem cells.
Catherine Gao, Jeffrey V. Leyton, Aaron D. Schimmer, Mark Minden, Raymond M. Reilly
PubMed abstract
Auger electron-emitting 111In-DTPA-NLS-CSL360 radioimmunoconjugates are cytotoxic to human acute myeloid leukemia (AML) cells displaying the CD123+/CD131- phenotype of leukemia stem cells.
Catherine Gao, Jeffrey V. Leyton, Aaron D. Schimmer, Mark Minden, Raymond M. Reilly
PubMed abstract
Advanced Drug Delivery Reviews, 2015, in press.
Radioimmunotherapy of cancer with high linear energy transfer (LET) radiation delivered by radionuclides emitting α-particles or Auger electrons.
Sadaf Aghevlian, Amanda J. Boyle, Raymond M. Reilly
PubMed abstract
Radioimmunotherapy of cancer with high linear energy transfer (LET) radiation delivered by radionuclides emitting α-particles or Auger electrons.
Sadaf Aghevlian, Amanda J. Boyle, Raymond M. Reilly
PubMed abstract
Leukemia Research Reports , 2015, 4(2):55-9.
A radiolabeled antibody targeting CD123(+) leukemia stem cells - initial radioimmunotherapy studies in NOD/SCID mice engrafted with primary human AML.
Jeffrey V. Leyton, Catherine Gao, Brent Williams, Armand Keating, Mark Minden, Raymond M. Reilly
PubMed abstract
A radiolabeled antibody targeting CD123(+) leukemia stem cells - initial radioimmunotherapy studies in NOD/SCID mice engrafted with primary human AML.
Jeffrey V. Leyton, Catherine Gao, Brent Williams, Armand Keating, Mark Minden, Raymond M. Reilly
PubMed abstract
Biomacromolecules, 2015, 16(11):3613-23.
Metal-Chelating Polymers (MCPs) with Zwitterionic Pendant Groups Complexed to Trastuzumab Exhibit Decreased Liver Accumulation Compared to Polyanionic MCP Immunoconjugates.
Peng Liu, Amanda J. Boyle, Yijie Lu, Jarrett Adams, Yuechuan Chi, Raymond M. Reilly,and Mitchell A. Winnik
PubMed abstract
Metal-Chelating Polymers (MCPs) with Zwitterionic Pendant Groups Complexed to Trastuzumab Exhibit Decreased Liver Accumulation Compared to Polyanionic MCP Immunoconjugates.
Peng Liu, Amanda J. Boyle, Yijie Lu, Jarrett Adams, Yuechuan Chi, Raymond M. Reilly,and Mitchell A. Winnik
PubMed abstract
Journal of Nuclear Medicine, 2015, 57(3):444-52.
Dual Receptor-Targeted Radioimmunotherapy of Human Breast Cancer Xenografts in Athymic Mice Co-Expressing HER2 and EGFR using 177Lu- or 111In-Labeled Bispecific Radioimmunoconjugates.
Eva J. Razumienko, Jason C. Chen , Zhongli Cai , Conrad Chan and Raymond M. Reilly
PubMed abstract
Dual Receptor-Targeted Radioimmunotherapy of Human Breast Cancer Xenografts in Athymic Mice Co-Expressing HER2 and EGFR using 177Lu- or 111In-Labeled Bispecific Radioimmunoconjugates.
Eva J. Razumienko, Jason C. Chen , Zhongli Cai , Conrad Chan and Raymond M. Reilly
PubMed abstract
Journal of Controlled Release, 2015, 219:295-312.
Integration of imaging into clinical practice to assess the delivery and performance of macromolecular and nanotechnology-based oncology therapies.
Tara Spence, Raquel De Souza, Yannan Dou, Shawn Stapleton, Raymond M. Reilly, Christine Allen
PubMed abstract
Integration of imaging into clinical practice to assess the delivery and performance of macromolecular and nanotechnology-based oncology therapies.
Tara Spence, Raquel De Souza, Yannan Dou, Shawn Stapleton, Raymond M. Reilly, Christine Allen
PubMed abstract
Molecular Pharmaceutics, 2015, 12(11):3963-72.
Radiation Nanomedicine for EGFR-Positive Breast Cancer: Panitumumab-Modified Gold Nanoparticles Complexed to the β‑Particle-Emitter, 177Lu
Simmyung Yook, Zhongli Cai, Yijie Lu, Mitchell A. Winnik, Jean-Philippe Pignol,and Raymond M. Reilly
PubMed abstract
Radiation Nanomedicine for EGFR-Positive Breast Cancer: Panitumumab-Modified Gold Nanoparticles Complexed to the β‑Particle-Emitter, 177Lu
Simmyung Yook, Zhongli Cai, Yijie Lu, Mitchell A. Winnik, Jean-Philippe Pignol,and Raymond M. Reilly
PubMed abstract
Nuclear Medicine and Biology, 2015, 42(12):931-8.
A comparison of non-biologically active truncated EGF (EGFt) and full-length hEGF for delivery of Auger electron-emitting (111)In to EGFR-positive breast cancer cells and tumor xenografts in athymic mice.
Clara Panosa, Humphrey Fonge, Montserrat Ferrer-Batallé, Javier A. Menéndez, Anna Massaguer, Rafael De Llorens,Raymond M. Reilly
PubMed abstract
A comparison of non-biologically active truncated EGF (EGFt) and full-length hEGF for delivery of Auger electron-emitting (111)In to EGFR-positive breast cancer cells and tumor xenografts in athymic mice.
Clara Panosa, Humphrey Fonge, Montserrat Ferrer-Batallé, Javier A. Menéndez, Anna Massaguer, Rafael De Llorens,Raymond M. Reilly
PubMed abstract
Molecular Pharmaceutics , 2015, 12(6):1951-60.
Trastuzumab Labeled to High Specific Activity with (111)In by Site-Specific Conjugation to a Metal-Chelating Polymer Exhibits Amplified Auger Electron-Mediated Cytotoxicity on HER2-Positive Breast Cancer Cells
Ghislaine Ngo Ndjock Mbong, Yijie Lu, Conrad Chan, Zhongli Cai, Peng Liu, Amanda J. Boyle, Mitchell A. Winnik, and Raymond M. Reilly
PubMed abstract
Trastuzumab Labeled to High Specific Activity with (111)In by Site-Specific Conjugation to a Metal-Chelating Polymer Exhibits Amplified Auger Electron-Mediated Cytotoxicity on HER2-Positive Breast Cancer Cells
Ghislaine Ngo Ndjock Mbong, Yijie Lu, Conrad Chan, Zhongli Cai, Peng Liu, Amanda J. Boyle, Mitchell A. Winnik, and Raymond M. Reilly
PubMed abstract
Bioconjugate Chemistry, 2015, 15;26(4):625-32.
Advancing Novel Molecular Imaging Agents from Preclinical Studies to First-in-Humans Phase I Clinical Trials in Academia—A Roadmap for Overcoming Perceived Barriers.
Raymond Reilly, Karen Lam, Conrad Chan, Mark Levine.
PubMed abstract
Advancing Novel Molecular Imaging Agents from Preclinical Studies to First-in-Humans Phase I Clinical Trials in Academia—A Roadmap for Overcoming Perceived Barriers.
Raymond Reilly, Karen Lam, Conrad Chan, Mark Levine.
PubMed abstract
Nuclear Medicine and Biology, 2015, 42(2):78-84.
Preclinical pharmacokinetics, biodistribution, radiation dosimetry and acute toxicity studies required for regulatory approval of a Clinical Trial Application for a Phase I/II clinical trial of 111In-BzDTPA-pertuzumab.
Lam K, Chan C, Done SJ, Levine MN, Reilly RM.
PubMed abstract
Preclinical pharmacokinetics, biodistribution, radiation dosimetry and acute toxicity studies required for regulatory approval of a Clinical Trial Application for a Phase I/II clinical trial of 111In-BzDTPA-pertuzumab.
Lam K, Chan C, Done SJ, Levine MN, Reilly RM.
PubMed abstract
Nuclear Medicine and Biology, 2015, 42(2):71-7.
MicroPET/CT Imaging of Patient-Derived Pancreatic Cancer Xenografts Implanted Subcutaneously or Orthotopically in NOD-scid Mice using 64Cu-NOTA-Panitumumab F(abʹ)2 Fragments.
Boyle AJ, Cao P, Hedley DW, Sidhu SS, Winnik MA, Reilly RM.
PubMed abstract
MicroPET/CT Imaging of Patient-Derived Pancreatic Cancer Xenografts Implanted Subcutaneously or Orthotopically in NOD-scid Mice using 64Cu-NOTA-Panitumumab F(abʹ)2 Fragments.
Boyle AJ, Cao P, Hedley DW, Sidhu SS, Winnik MA, Reilly RM.
PubMed abstract
2014
Leukemia Research, 2014, 38(11):1367-73.
MicroSPECT/CT imaging of primary human AML engrafted into the bone marrow and spleen of NOD/SCID mice using 111In-DTPA-NLSCSL360 radioimmunoconjugates recognizing the CD123+/CD131- epitope expressed by leukemia stem cells.
Leyton, J.V., Williams, B., Keating, A., Minden, M., Reilly, R.M.
PubMed abstract
MicroSPECT/CT imaging of primary human AML engrafted into the bone marrow and spleen of NOD/SCID mice using 111In-DTPA-NLSCSL360 radioimmunoconjugates recognizing the CD123+/CD131- epitope expressed by leukemia stem cells.
Leyton, J.V., Williams, B., Keating, A., Minden, M., Reilly, R.M.
PubMed abstract
American Journal of Nuclear Medicine and Molecular Imaging, 2014;4:181-92.
Phase I Trial to Evaluate the Tumor and Normal Tissue Uptake, Radiation Dosimetry and Safety of 111In-DTPA-Human Epidermal Growth Factor in Patients with Metastatic EGFR-Positive Breast Cancer.
Vallis, K.A., Reilly, R.M., Scollard, D.A., Merante, P., Brade, A., Velauthapillai, S., Caldwell, C., Chan, I., Freeman, M., Lockwood, G., Miller, N.A., Oza, A., Petronis, J., Sabate, K.
PubMed abstract
Phase I Trial to Evaluate the Tumor and Normal Tissue Uptake, Radiation Dosimetry and Safety of 111In-DTPA-Human Epidermal Growth Factor in Patients with Metastatic EGFR-Positive Breast Cancer.
Vallis, K.A., Reilly, R.M., Scollard, D.A., Merante, P., Brade, A., Velauthapillai, S., Caldwell, C., Chan, I., Freeman, M., Lockwood, G., Miller, N.A., Oza, A., Petronis, J., Sabate, K.
PubMed abstract
Applied Radiation and Isotopes, 2014; 95:135-42.
Kit for the preparation of 111In-labeled pertuzumab injection for imaging response of HER2-positive breast cancer to trastuzumab (Herceptin).
Lam K, Scollard DA, Chan C, Levine MN, Reilly RM.
PubMed abstract
Kit for the preparation of 111In-labeled pertuzumab injection for imaging response of HER2-positive breast cancer to trastuzumab (Herceptin).
Lam K, Scollard DA, Chan C, Levine MN, Reilly RM.
PubMed abstract
Biomacromolecules, 2014;15(3):715-725.
Intracellular routing in breast cancer cells of streptavidin-conjugated trastuzumab fab fragments linked to biotinylated doxorubicin-functionalized metal chelating polymers.
Liu P, Cai Z, Kang J, Boyle AJ, Lu Y, Mbong GNN, Reilly RM, Winnik MA.
PubMed abstract
Intracellular routing in breast cancer cells of streptavidin-conjugated trastuzumab fab fragments linked to biotinylated doxorubicin-functionalized metal chelating polymers.
Liu P, Cai Z, Kang J, Boyle AJ, Lu Y, Mbong GNN, Reilly RM, Winnik MA.
PubMed abstract
Biomacromolecules, 2014; 15: 2027-2037.
Synthesis of polyglutamide-based metal-chelating polymers and their site-specific conjugation to trastuzumab for auger electron radioimmunotherapy.
Yijie Lu, Ghislaine Ngo Ndjock Mbong, Peng Liu, Conrad Chan, Zhongli Cai, Dirk Weinrich, Amanda J. Boyle, Raymond M. Reilly, and Mitchell A. Winnik.
PubMed abstract
Synthesis of polyglutamide-based metal-chelating polymers and their site-specific conjugation to trastuzumab for auger electron radioimmunotherapy.
Yijie Lu, Ghislaine Ngo Ndjock Mbong, Peng Liu, Conrad Chan, Zhongli Cai, Dirk Weinrich, Amanda J. Boyle, Raymond M. Reilly, and Mitchell A. Winnik.
PubMed abstract
Nuclear Medicine and Biology, 2014; 41: 377-383.
The human polynucleotide kinase/phosphatase (hPNKP) inhibitor A12B4C3 radiosensitizes human myeloid leukemia cells to Auger electron-emitting anti-CD123 111In-NLS-7G3 radioimmunoconjugates.
Arman Zereshkian, Jeffrey V. Leyton, Zhongli Cai, Dane Bergstrom, Michael Weinfeld, Raymond M. Reilly.
PubMed abstract
The human polynucleotide kinase/phosphatase (hPNKP) inhibitor A12B4C3 radiosensitizes human myeloid leukemia cells to Auger electron-emitting anti-CD123 111In-NLS-7G3 radioimmunoconjugates.
Arman Zereshkian, Jeffrey V. Leyton, Zhongli Cai, Dane Bergstrom, Michael Weinfeld, Raymond M. Reilly.
PubMed abstract
Nuclear Medicine and Biology, 2014;41:377-83.
The polynucleotide kinase/phosphatase inhibitor A12B4C3 radiosensitizes AML-5 human myeloid leukemia cells to the cytotoxic effects of the Auger electrons emitted by 111In-NLS-7G3 anti-CD123 radioimmunoconjugates.
Zareshkian, A., Leyton, J.V., Cai, Z., Bergstrom, D., Weinfeld, M., Reilly, R.M.
Abstract
The polynucleotide kinase/phosphatase inhibitor A12B4C3 radiosensitizes AML-5 human myeloid leukemia cells to the cytotoxic effects of the Auger electrons emitted by 111In-NLS-7G3 anti-CD123 radioimmunoconjugates.
Zareshkian, A., Leyton, J.V., Cai, Z., Bergstrom, D., Weinfeld, M., Reilly, R.M.
Abstract
Biomacromolecules, 2014;15:715-25.
Cell internalization of radioimmunoconjugates based on trastuzumab Fab fragments and biotinylated doxorubicin-containing metal chelating polymer.
Liu, P., Cai, Z., Kang, J., Boyle, A.J., Adams, J., Lu, Y., Mbong, G.N.N., Sidhu, S., Reilly, R.M., Winnik, M.A.
PubMed abstract
Cell internalization of radioimmunoconjugates based on trastuzumab Fab fragments and biotinylated doxorubicin-containing metal chelating polymer.
Liu, P., Cai, Z., Kang, J., Boyle, A.J., Adams, J., Lu, Y., Mbong, G.N.N., Sidhu, S., Reilly, R.M., Winnik, M.A.
PubMed abstract
2013
Pharmaceutical Research, 2013; 30(1):104-116.
The effect of metal-chelating polymers (MCPs) for 111In complexed via the streptavidin-biotin system to trastuzumab fab fragments on tissue distribution in mice.
Boyle AJ, Liu P, Lu Y, Weinrich D, Scollard DA, Mbong GNN, Winnik MA, Reilly RM.
PubMed abstract
The effect of metal-chelating polymers (MCPs) for 111In complexed via the streptavidin-biotin system to trastuzumab fab fragments on tissue distribution in mice.
Boyle AJ, Liu P, Lu Y, Weinrich D, Scollard DA, Mbong GNN, Winnik MA, Reilly RM.
PubMed abstract
Journal of Medical Physics, 2013; 40:114101.
Investigation of the effects of cell model and subcellular location of gold nanoparticles on nuclear dose enhancement factors using Monte Carlo simulation.
Zhongli Cai, Jean-Philippe Pignol, Niladri Chattopadhyay, Yongkyu Luke Kwon, Eli Lechtman, Raymond M. Reilly.
PubMed abstract
Investigation of the effects of cell model and subcellular location of gold nanoparticles on nuclear dose enhancement factors using Monte Carlo simulation.
Zhongli Cai, Jean-Philippe Pignol, Niladri Chattopadhyay, Yongkyu Luke Kwon, Eli Lechtman, Raymond M. Reilly.
PubMed abstract
Pharmaceutical Research, 2013; 30:1999–2009.
Trastuzumab Labeled to High Specific Activity with 111In by Conjugation to G4 PAMAM Dendrimers Derivatized with Multiple DTPA Chelators Exhibits Increased Cytotoxic Potency on HER2-Positive Breast Cancer Cells.
Conrad Chan, Zhongli Cai, Raymond M. Reilly.
PubMed abstract
Trastuzumab Labeled to High Specific Activity with 111In by Conjugation to G4 PAMAM Dendrimers Derivatized with Multiple DTPA Chelators Exhibits Increased Cytotoxic Potency on HER2-Positive Breast Cancer Cells.
Conrad Chan, Zhongli Cai, Raymond M. Reilly.
PubMed abstract
Physics in Medicine and Biology, 2013; 58: 3075-3087.
A Monte Carlo-based model of gold nanoparticle radiosensitization accounting for increased radiobiological effectiveness.
E. Lechtman, S. Mashouf, N. Chattopadhyay, B. M. Keller, P. Lai, Z. Cai, , R. Reilly and J. P. Pignol.
PubMed abstract
A Monte Carlo-based model of gold nanoparticle radiosensitization accounting for increased radiobiological effectiveness.
E. Lechtman, S. Mashouf, N. Chattopadhyay, B. M. Keller, P. Lai, Z. Cai, , R. Reilly and J. P. Pignol.
PubMed abstract
Breast Cancer Research and Treatment, 2013; 137: 81-91.
Molecularly Targeted Gold Nanoparticles Enhance the Radiation Response of Breast Cancer Cells and Tumor Xenografts to X-Radiation.
Niladri Chattopadhyay, Zhongli Cai, Yongkyu Luke Kwon, Eli Lechtman, Jean-Philippe Pignol, and Raymond M Reilly.
PubMed abstract
Molecularly Targeted Gold Nanoparticles Enhance the Radiation Response of Breast Cancer Cells and Tumor Xenografts to X-Radiation.
Niladri Chattopadhyay, Zhongli Cai, Yongkyu Luke Kwon, Eli Lechtman, Jean-Philippe Pignol, and Raymond M Reilly.
PubMed abstract
Molecular Pharmaceutics, 2013;10:4229-41.
Active targeting of block copolymer micelles leads to increased tumor uptake and nuclear localization.
Hoang, B., Ekdawi, S., Reilly, R.M., Allen, C.
PubMed abstract
Active targeting of block copolymer micelles leads to increased tumor uptake and nuclear localization.
Hoang, B., Ekdawi, S., Reilly, R.M., Allen, C.
PubMed abstract
PLOS One, 2013; 8:e69325.
Development of an epidermal growth factor derivative with EGFR blocking activity.
Panosa, C., Tebar, F., Batalle, MF, Fonge, H., Seno, M., Reilly, R.M., Massaguer, A., De Llorens, R.
PubMed abstract
Development of an epidermal growth factor derivative with EGFR blocking activity.
Panosa, C., Tebar, F., Batalle, MF, Fonge, H., Seno, M., Reilly, R.M., Massaguer, A., De Llorens, R.
PubMed abstract
PLOS One, 2013; 8:e64069.
Estrone-3sulphate, a potential novel ligand for targeting breast cancers.
Banerjee, N., Fonge, H., Milkhail, A., Reilly, R.M., Bendayan, R., Allen, C.
PubMed abstract
Estrone-3sulphate, a potential novel ligand for targeting breast cancers.
Banerjee, N., Fonge, H., Milkhail, A., Reilly, R.M., Bendayan, R., Allen, C.
PubMed abstract
Breast Cancer Research and Treatment, 2013; 138:709-18.
MicroSPECT/CT imaging of co-expressed HER2 and EGFR on subcutaneous human tumor xenografts in athymic mice using 111In-labeled bispecific radioimmunoconjugates.
Razumienko, E., Dryden, L., Scollard, D., Reilly, R.M.
PubMed abstract
MicroSPECT/CT imaging of co-expressed HER2 and EGFR on subcutaneous human tumor xenografts in athymic mice using 111In-labeled bispecific radioimmunoconjugates.
Razumienko, E., Dryden, L., Scollard, D., Reilly, R.M.
PubMed abstract
Nuclear Medicine and Biology, 2013; 40:630-637.
Phase I trial of intraoperative detection of tumor margins in patients with HER2-positive carcinoma of the breast following administration of 111In-DTPA-trastuzumab Fab fragments.
Holloway, C., Scollard, D.A., Caldwell, C, Kahn, H., Reilly, R.M.
PubMed abstract
Phase I trial of intraoperative detection of tumor margins in patients with HER2-positive carcinoma of the breast following administration of 111In-DTPA-trastuzumab Fab fragments.
Holloway, C., Scollard, D.A., Caldwell, C, Kahn, H., Reilly, R.M.
PubMed abstract
Cancer Biotherapy & Radiopharmaceuticals, 2013; 28:254-9.
Positron-emission tomography imaging of the TSPO with [18F]FEPPA in a preclinical breast cancer model.
Vasdev, N., Green, D., Vines, D., McLarty, K., McCormick, P., Moran, M., Houle, S., Wilson, A., Reilly, R.M.
PubMed abstract
Positron-emission tomography imaging of the TSPO with [18F]FEPPA in a preclinical breast cancer model.
Vasdev, N., Green, D., Vines, D., McLarty, K., McCormick, P., Moran, M., Houle, S., Wilson, A., Reilly, R.M.
PubMed abstract
2012
Biomacromolecules, 2012; 13(5):1296-1306.
Effect of pendant group structure on the hydrolytic stability of polyaspartamide polymers under physiological conditions.
Lu Y, Chau M, Boyle AJ, Liu P, Niehoff A, Weinrich D, Reilly RM, Winnik MA.
PubMed abstract
Effect of pendant group structure on the hydrolytic stability of polyaspartamide polymers under physiological conditions.
Lu Y, Chau M, Boyle AJ, Liu P, Niehoff A, Weinrich D, Reilly RM, Winnik MA.
PubMed abstract
Biomacromolecules, 2012;13(9):2831-42.
Biotinilyated polyacrylamide-based metal-chelating polymers and their influence on antigen recognition following conjugation to a trastuzumab fab fragment.
Liu P, Boyle AJ, Lu Y, Reilly RM, Winnik MA.
PubMed abstract
Biotinilyated polyacrylamide-based metal-chelating polymers and their influence on antigen recognition following conjugation to a trastuzumab fab fragment.
Liu P, Boyle AJ, Lu Y, Reilly RM, Winnik MA.
PubMed abstract
Molecular Pharmaceutics, 2012; 9: 2168-2179.
Role of Antibody Mediated Tumor Targeting and Route of Administration in Nanoparticle Tumor Accumulation In Vivo.
Niladri Chattopadhyay, Humphrey Fonge, Zhongli Cai, Deborah Scollard, Eli Lechtman, Susan J. Done, Jean-Philippe Pignol, and Raymond M Reilly.
PubMed abstract
Role of Antibody Mediated Tumor Targeting and Route of Administration in Nanoparticle Tumor Accumulation In Vivo.
Niladri Chattopadhyay, Humphrey Fonge, Zhongli Cai, Deborah Scollard, Eli Lechtman, Susan J. Done, Jean-Philippe Pignol, and Raymond M Reilly.
PubMed abstract
Breast Cancer Research and Treatment, 2012; 135: 189-200.
111In-Bn-DTPA-nimotuzumab with/without modification with nuclear translocation sequence (NLS) peptides: an Auger electron-emitting radioimmunotherapeutic agent for EGFRpositive and trastuzumab (Herceptin)-resistant breast cancer.
Aisha Fasih, Humphrey Fonge, Zhongli Cai, Jeffrey V. Leyton, Ilia Tikhomirov, Susan J. Done , Raymond M. Reilly.
PubMed abstract
111In-Bn-DTPA-nimotuzumab with/without modification with nuclear translocation sequence (NLS) peptides: an Auger electron-emitting radioimmunotherapeutic agent for EGFRpositive and trastuzumab (Herceptin)-resistant breast cancer.
Aisha Fasih, Humphrey Fonge, Zhongli Cai, Jeffrey V. Leyton, Ilia Tikhomirov, Susan J. Done , Raymond M. Reilly.
PubMed abstract
2011
International Journal of Radiation Biology, 2011; 87: 1135 – 1146
Optimized digital counting colonies of clonogenic assays using ImageJ software and customized macros: comparison with manual counting.
Zhongli Cai, Niladri Chattopadhyay, Wenchao Jessica Liu, Conrad Chan, Jean-Philippe Pignol, and Raymond M. Reilly.
PubMed abstract
Optimized digital counting colonies of clonogenic assays using ImageJ software and customized macros: comparison with manual counting.
Zhongli Cai, Niladri Chattopadhyay, Wenchao Jessica Liu, Conrad Chan, Jean-Philippe Pignol, and Raymond M. Reilly.
PubMed abstract
Physics in Medicine and Biology, 2011; 56:4631-4647.
Implications on clinical scenario of gold nanoparticle radiosensitization in regards to photon energy, nanoparticle size, concentration and location.
E. Lechtman, N. Chattopadhyay, Z. Cai, S. Mashouf, R. Reilly and J. P. Pignol.
PubMed abstract
Implications on clinical scenario of gold nanoparticle radiosensitization in regards to photon energy, nanoparticle size, concentration and location.
E. Lechtman, N. Chattopadhyay, Z. Cai, S. Mashouf, R. Reilly and J. P. Pignol.
PubMed abstract
EJNMMI research, 2011; 1(1):15.
A comparison of 111In- or 64Cu-DOTA-trastuzumab Fab fragments for imaging subcutaneous HER2-positive tumor xenografts in athymic mice using microSPECT/CT or microPET/CT.
Chan C, Scollard DA, McLarty K, Smith S, Reilly RM.
PubMed abstract
A comparison of 111In- or 64Cu-DOTA-trastuzumab Fab fragments for imaging subcutaneous HER2-positive tumor xenografts in athymic mice using microSPECT/CT or microPET/CT.
Chan C, Scollard DA, McLarty K, Smith S, Reilly RM.
PubMed abstract
Nuclear Medicine and Biology, 2011; 38(7):953-9.
Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice.
McLarty K, Moran MD, Scollard DA, Chan C, Sabha N, Mukherjee J, Guha A,McLaurin J, Nitz M, Houle S, Wilson AA, Reilly RM, Vasdev N.
PubMed abstract
Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice.
McLarty K, Moran MD, Scollard DA, Chan C, Sabha N, Mukherjee J, Guha A,McLaurin J, Nitz M, Houle S, Wilson AA, Reilly RM, Vasdev N.
PubMed abstract
Nuclear Medicine and Biology, 2011; 38(1):129-36.
A kit to prepare (111)In-DTPA-trastuzumab (Herceptin) Fab fragments injection under GMP conditions for imaging or radioimmunoguided surgery of HER2-positive breast cancer.
Scollard DA, Chan C, Holloway CM, Reilly RM.
PubMed abstract
A kit to prepare (111)In-DTPA-trastuzumab (Herceptin) Fab fragments injection under GMP conditions for imaging or radioimmunoguided surgery of HER2-positive breast cancer.
Scollard DA, Chan C, Holloway CM, Reilly RM.
PubMed abstract
2010
Molecular Pharmaceutics, 2010; 7: 2194–2206.
Design and Characterization of HER-2-Targeted Gold Nanoparticles for Enhanced X-radiation Treatment of Locally Advanced Breast Cancer.
Niladri Chattopadhyay, Zhongli Cai, Jean-Philippe Pignol, Brian Keller, Eli Lechtman, Reina Bendayan, and Raymond M. Reilly.
PubMed abstract
Design and Characterization of HER-2-Targeted Gold Nanoparticles for Enhanced X-radiation Treatment of Locally Advanced Breast Cancer.
Niladri Chattopadhyay, Zhongli Cai, Jean-Philippe Pignol, Brian Keller, Eli Lechtman, Reina Bendayan, and Raymond M. Reilly.
PubMed abstract
Journal of Nuclear Medicine, 2010; 51: 1489.
Cellular dosimetry using the Geant4 monte carlo toolkit”.
Z. Cai, J. P. Pignol, C. Chan and R. M. Reilly.
Abstract
Cellular dosimetry using the Geant4 monte carlo toolkit”.
Z. Cai, J. P. Pignol, C. Chan and R. M. Reilly.
Abstract
Journal of Nuclear Medicine, 2010; 51: 462-470.
Cellular Dosimetry of 111In using Monte Carlo N-Particle (MCNP) Computer Code: Comparison with the Analytical Methods and Correlation with In Vitro Cytotoxicity,
Zhongli Cai, Jean-Philippe Pignol, Conrad Chan, and Raymond M. Reilly,
PubMed abstract
Cellular Dosimetry of 111In using Monte Carlo N-Particle (MCNP) Computer Code: Comparison with the Analytical Methods and Correlation with In Vitro Cytotoxicity,
Zhongli Cai, Jean-Philippe Pignol, Conrad Chan, and Raymond M. Reilly,
PubMed abstract
Nuclear Medicine and Biology, 2010; 37: 105-115.
111In- or 99mTc-labeled recombinant VEGF bioconjugates: in vitro evaluation of their cytotoxicity on porcine aortic endothelial cells overexpressing Flt-1 receptors.
Conrad Chan, Zhongli Cai, Ruifen Su, Raymond M. Reilly.
PubMed abstract
111In- or 99mTc-labeled recombinant VEGF bioconjugates: in vitro evaluation of their cytotoxicity on porcine aortic endothelial cells overexpressing Flt-1 receptors.
Conrad Chan, Zhongli Cai, Ruifen Su, Raymond M. Reilly.
PubMed abstract
2009
Journal of Nuclear Medicine, 2009; 50:1340-134.
Micro-SPECT/CT with 111In-DTPAPertuzumab Sensitively Detects Trastuzumab-Mediated HER2 Downregulation and Tumor Response in Athymic Mice Bearing MDA-MB-361 Human Breast Cancer Xenografts.
Kristin McLarty, Bart Cornelissen, Zhongli Cai, Deborah A. Scollard, Danny L. Costantini, Susan J. Done and Raymond M. Reilly.
PubMed abstract
Micro-SPECT/CT with 111In-DTPAPertuzumab Sensitively Detects Trastuzumab-Mediated HER2 Downregulation and Tumor Response in Athymic Mice Bearing MDA-MB-361 Human Breast Cancer Xenografts.
Kristin McLarty, Bart Cornelissen, Zhongli Cai, Deborah A. Scollard, Danny L. Costantini, Susan J. Done and Raymond M. Reilly.
PubMed abstract
International Journal of Radiation Biology, 2009; 85: 262-271.
Computational analysis of the number, area and density of g-H2AX foci in breast cancer cells exposed to 111In-DTPA-hEGF and g-rays using Image-J software.
Zhongli Cai, Katherine A. Vallis, and Raymond M. Reilly.
PubMed abstract
Computational analysis of the number, area and density of g-H2AX foci in breast cancer cells exposed to 111In-DTPA-hEGF and g-rays using Image-J software.
Zhongli Cai, Katherine A. Vallis, and Raymond M. Reilly.
PubMed abstract
